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M94A0706.TXT
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1994-10-21
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Document 0706
DOCN M94A0706
TI HIV related chronic reactive/suppurative airway disease: is CMV
important?
DT 9412
AU Parkin D; Pigott P; Dept. of HIV Medicine, Royal North Shore Hospital,
St Leonards,; NSW.
SO Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:28 (abstract no. TC5).
Unique Identifier : AIDSLINE ASHM5/94348949
AB We describe a case of HIV related chronic reactive/suppurative airway
disease in a non smoking 47 year old man. He had longstanding HIV
infection treated with sporadic AZT. His initial complication was
Pneumocystis carinii pneumonia in May 1992. He represented in August
1992 with a two month history of suppurative sinusitis, productive
cough, increasing shortness of breath, lethargy, myalgias and sweats.
CD4 Count was 280. Spirometry FEV 3.4, VC 3.6. Chest x-ray was clear.
Sputum unhelpful. There was no response to oral antibiotics. Induced
sputum in September 1992 showed an increased white cell count, but no
pathogens. Respiratory function tests showed restriction with decreased
DLCO. High dose Bactrim gave no improvement. In December 1992 he had
persisting symptoms and chest signs. Spirometry FEV 2.1, VC 2.9. Chest
x-ray was unchanged. He responded to antibiotic and steroid. There were
further relapses in February, March, April and May 1993, each time
responding to steroid and antibiotic and requiring maintenance oral
steroid. Admission was required in June 1993, for increasing shortness
of breath and cough. He had diffuse respiratory signs and hypoxia.
Bronchial biopsy revealed CMV. This case highlights the problem of
chronic reactive/suppurative airway disease in HIV and raises the
possibility of CMV being a contributing factor.
DE AIDS-Related Opportunistic Infections/*DIAGNOSIS/PATHOLOGY Biopsy Case
Report Cytomegalovirus Infections/*DIAGNOSIS/PATHOLOGY Diagnosis,
Differential Human Lung/PATHOLOGY Male Middle Age Pneumonia,
Viral/*DIAGNOSIS/PATHOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).